|
KMID : 0357220060180010065
|
|
Journal of Korean Society Physical Therapy
2006 Volume.18 No. 1 p.65 ~ p.73
|
|
|
The Effect of EA and TENS on GAP-43 Expression in Spinal Cord after Rat Sciatic Nerve Crush Injury
|
|
Lee Hyun-Min
Kim Jin-Sang
Park Eun-Se
Kim Min-Hee
Kim Souk-Boum
Kim Dong-Hyun
|
|
|
Abstract
|
|
|
Purpose: The purpose of this study was to identify the effect of electroacupuncture(EA) and transcutaneous electric nerve stimulation(TENS) after sciatic nerve crush injury in rats.
Methods: The EA for experimental group I (Exp I, n=15) and TENS for experimental group II (Exp II, n=15) was applied from post-injury day(PD) 1 to PD 14 after sciatic nerve injury using low frequency stimulator that gave electrical stimulation(15min/60Hz). In order observe the effect of EA and TENS, this study examined GAP-43 expression in rat lumbar spinal cord at the PD 1, PD 7 and PD 14. In addition, the stride length(SL) and toe out angle(TOA) were measured at the PD 7 and PD 4.
Results: Exp I and Exp II had higher GAP-43 immunoreactivity than control group(PD 1, 7, 14). The SL of Exp I and Exp II were significantly higher than control group(PD 7, 14). The TOA of Exp I and Exp II were significantly lower than control group(PD 7, 14).
Conclusion: EA and TENS application increased motor nerve recovery and expression of GAP-43 immunoreactivity after sciatic nerve crush injury. Therefore effect of TENS and EA had similar effect on nerve regeneration and functional recovery.
|
|
|
KEYWORD
|
|
|
GAP-43, EA, TENS, Sciatic nerve injury
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|